Search results for "Delivery vehicle"
showing 5 items of 5 documents
Branch-and-Cut for the Split Delivery Vehicle Routing Problem with Time Windows
2019
The split delivery vehicle routing problem with time windows (SDVRPTW) is a notoriously hard combinatorial optimization problem. First, it is hard to find a useful compact mixed-integer programming (MIP) formulation for the SDVRPTW. Standard modeling approaches either suffer from inherent symmetries (mixed-integer programs with a vehicle index) or cannot exactly capture all aspects of feasibility. Because of the possibility to visit customers more than once, the standard mechanisms to propagate load and time along the routes fail. Second, the lack of useful formulations has rendered any direct MIP-based approach impossible. Up to now, the most effective exact algorithms for the SDVRPTW hav…
Stabilized branch-price-and-cut for the commodity-constrained split delivery vehicle routing problem
2019
Abstract In the commodity-constrained split delivery vehicle routing problem (C-SDVRP), customer demands are composed of sets of different commodities. The C-SDVRP asks for a minimum-distance set of routes such that all customer demands are met and vehicle capacities are respected. Moreover, whenever a commodity is delivered by a vehicle to a customer, the entire amount requested by this customer must be provided. Different commodities demanded by one customer, however, can be delivered by different vehicles. Thus, the C-SDVRP is a relaxation of the capacitated vehicle routing problem and a restriction of the split delivery vehicle routing problem. For its exact solution, we propose a branc…
The Split Delivery Vehicle Routing Problem with Time Windows and Customer Inconvenience Constraints
2019
In classical routing problems, each customer is visited exactly once. By contrast, when allowing split deliveries, customers may be served through multiple visits. This potentially results in substantial savings in travel costs. Even if split deliveries are beneficial to the transport company, several visits may be undesirable on the customer side: At each visit the customer has to interrupt his primary activities and handle the goods receipt. The contribution of the present paper consists in a thorough analysis of the possibilities and limitations of split delivery distribution strategies. To this end, we investigate two different types of measures for limiting customer inconvenience (a m…
Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy.
2021
Gene-directed enzyme prodrug therapy (GDEPT) has been intensively studied as a promising new strategy of prodrug delivery, with its main advantages being represented by an enhanced efficacy and a reduced off-target toxicity of the active drug. In recent years, numerous therapeutic systems based on GDEPT strategy have entered clinical trials. In order to deliver the desired gene at a specific site of action, this therapeutic approach uses vectors divided in two major categories, viral vectors and non-viral vectors, with the latter being represented by chemical delivery agents. There is considerable interest in the development of non-viral vectors due to their decreased immunogenicity, higher…
Extracellular Vesicles from Plants: Current Knowledge and Open Questions.
2021
The scientific interest in the beneficial properties of natural substances has been recognized for decades, as well as the growing attention in extracellular vesicles (EVs) released by different organisms, in particular from animal cells. However, there is increasing interest in the isolation and biological and functional characterization of these lipoproteic structures in the plant kingdom. Similar to animal vesicles, these plant-derived extracellular vesicles (PDEVs) exhibit a complex content of small RNAs, proteins, lipids, and other metabolites. This sophisticated composition enables PDEVs to be therapeutically attractive. In this review, we report and discuss current knowledge on PDEVs…